17β-estradiol maintains extracellular matrix homeostasis of nucleus pulposus cells by activating p70 S6K1 signaling pathway
In summary, 17β-estradiol mitigates IVDD progression by maintaining ECM homeostasis and inhibiting NPCs apoptosis through activation of the p70 S6K1 signaling pathway downstream of mTOR.
Authors
- Sidong Yang (ORCID: https://orcid.org/0000-0003-2342-4714)
- Dalong Yang (ORCID: https://orcid.org/0000-0003-0090-2277)
- Zhaohui Li (ORCID: https://orcid.org/0000-0002-4132-658X)
- Wei Zhang (ORCID: https://orcid.org/0009-0007-7082-1014)
- Tao Liu (ORCID: https://orcid.org/0009-0005-8717-1260)
- Guobin Liu (ORCID: https://orcid.org/0000-0003-2801-8264)
- Xuzhao Guo
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- Hebei General Hospital (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fcell.2025.1564458
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00