Integrated analysis of myeloperoxidase in gastric health and cancer: associations with pepsinogen levels, immune regulation, and prognosis in a large healthy population-based and TCGA cohorts
This study highlights the distinct roles of MPO in gastric mucosal injury and gastric cancer. In healthy individuals, MPO is associated with markers of gastric mucosal damage, while in GA patients, MPO serves as a prognostic biomarker linked to immune dysregulation. These findings suggest that MPO may be a potential target for monitoring or intervention in gastric mucosal injury and gastric cancer.
Authors
- Junteng Zhou (ORCID: https://orcid.org/0000-0002-4257-0488)
- Qi Kong (ORCID: https://orcid.org/0000-0002-7077-8905)
- Xiaojing Liu (ORCID: https://orcid.org/0000-0002-2066-7078)
- Yan Huang (ORCID: https://orcid.org/0000-0002-2072-0190)
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- National Clinical Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1590257
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Sichuan University
- West China Hospital, Sichuan University