Long-term fasting and its influence on inflammatory biomarkers: A comprehensive scoping review
This review finds limited and inconsistent evidence on prolonged fasting's effects on inflammation, with varied study designs and lack of standard protocols. Overall, prolonged fasting appears to lead to an increase in inflammation that may represent an adaptive mechanism. Future research, particularly randomized controlled trials, is needed to assess the long-term impacts of fasting on inflammation and metabolic diseases across different populations.
Authors
- Andrius Masedunskas (ORCID: https://orcid.org/0000-0002-4533-5467)
- Luigi Fontana (ORCID: https://orcid.org/0000-0001-8500-5537)
- Lee Smith (ORCID: https://orcid.org/0000-0002-5340-9833)
- María Lastra Cagigas (ORCID: https://orcid.org/0000-0001-5464-2349)
- Claudio Franceschi (ORCID: https://orcid.org/0000-0001-9841-6386)
- Isabella De Ciutiis
- Shadia Djakovic
Institutions
- The University of Sydney (AU)
- Anglia Ruskin University (GB)
- N. I. Lobachevsky State University of Nizhny Novgorod (RU)
Publication Details
- Journal
- Ageing Research Reviews
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.arr.2025.102797
- Citations
- 10
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 11.64
Funders
- Australian Youth and Health Foundation
- National Health and Medical Research Council