Remarkable Enhancement of the Radiotherapeutic Efficacy via Targeted Reduction of Hypoxic Conditions and Depletion of Intracellular Glutathione Utilizing Cu<sub>2–<i>x</i></sub>Se@Pt Nanoplatforms
Integrating multifunctional nanostructures to improve tumor microenvironment-mediated radiotherapy (RT) resistance combined with photothermal ablation represents a novel approach to killing tumor cells. In this work, we developed a synergistic nanoplatform (Cu2–xSe@Pt, CS@Pt) capable of simultaneously addressing hypoxia, glutathione (GSH) overexpression, and energy deposition limitations. The mean lethal dose of radiation for KYSE30 tumor cells was significantly reduced by approximately 60% after CS@Pt incubation, decreasing from 4.92 to 1.97 Gy. Additionally, CS nanoparticles exhibit effective photothermal properties, enabling the CS@Pt formulation to integrate bioimaging with photothermal therapy (PTT) and RT, thereby creating a multifunctional nanoplatform for comprehensive tumor treatment. Both in vitro and in vivo experiments demonstrated that the combination of RT and PTT achieved complete tumor ablation, exhibiting excellent biosafety and potential for clinical translation.
Authors
- Wenxuan Fan
- Jiayi Li (ORCID: https://orcid.org/0009-0001-2999-0496)
- Fengqi Zhang (ORCID: https://orcid.org/0000-0002-4091-2464)
- Mingkai Liu (ORCID: https://orcid.org/0000-0001-9060-848X)
- Yingyan Yu (ORCID: https://orcid.org/0000-0002-3585-3252)
- Shegan Gao (ORCID: https://orcid.org/0000-0001-9055-1479)
- Kwun Nam Hui (ORCID: https://orcid.org/0000-0002-3008-8571)
- Anqi Ji (ORCID: https://orcid.org/0009-0006-4129-9266)
- Haoyan Cheng (ORCID: https://orcid.org/0000-0002-6328-1546)
- Peng Yang (ORCID: https://orcid.org/0000-0002-2746-744X)
- Yan Yan (ORCID: https://orcid.org/0000-0002-4618-7654)
- Hao Hu (ORCID: https://orcid.org/0000-0001-5999-3842)
- Linlin Shi
- Beng Ma
Institutions
- Henan University of Science and Technology (CN)
- University of Macau (MO)
- First Affiliated Hospital of Henan University of Science and Technology (CN)
- Anhui University of Technology (CN)
Publication Details
- Journal
- ACS Materials Letters
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1021/acsmaterialslett.5c00585
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- Natural Science Foundation for Distinguished Young Scholars of Anhui Province
- Health Commission of Henan Province
- National Natural Science Foundation of China
- Henan University of Science and Technology
- Natural Science Foundation of Henan Province
- Science and Technology Department of Henan Province
- National Key Research and Development Program of China