PRIMING THE CARDIOPULMONARY BYPASS CIRCUIT WITH FRESH FROZEN PLASMA REDUCES BLEEDING IN COMPLEX CARDIAC SURGERY

Background: Every year, about 400 000 open-heart procedures are conducted utilizing the cardiopulmonary bypass (CPB) technique.1 In the majority of disciplines associated with on-pump cardiac surgery, numerous studies have been undertaken to investigate factors such as coagulation cascades, surgical stress response, blood transfusion demand, inflammatory indicators, and hypoxia. The purpose of this study was to examine if fresh frozen plasma (FFP) could potentially use to prime the cardiopulmonary bypass (CPB) circuit and minimize bleeding in complicated cardiac surgery. This comparative cross sectional study was carried out in department of Cardiac Surgery, PIC, Lahore from May 10, 2022 to May 10, 2023, this study. Methods: A sample size of 40 subjects in each group and a total sample size of 80 patients were enrolled. A random allocation method was implemented for classifying the patients into the control or case (FFP) groups. Results: The average age of participants in Group-A was 47.96 ± 5.14 years, whereas in Group-B, it was 50.12±6.09 years. Group A comprised 25 males (62.5%) and 15 females (37.5%), whereas Group B comprised 23 males (57.5%) and 17 females (42.5%). In our data there was significant difference found in packed cells infusions in prime 70.38±33.97 and 96.15±24.15 with p-value 0.05 and FFP and platelets transfusions with p-value 0.03 and 0.02 respectively. However no difference was found in packed cells infusions and FFP infusions intra-operatively between both groups with p-values 0.61 and 0.35 respectively. Conclusion: The results of this study showed that, the inclusion of FFP in pump priming for cardiac surgery reduces packed cells and platelets requirements