Synthesis of Oxa-spiro-bicyclo[2.1.1]hexane by Au/Sc Relay Catalysis
A new Au/Sc relay catalysis approach has been developed for the rapid construction of oxa-spiro-bicyclo[2.1.1]hexanes under mild conditions. This cascade reaction proceeds via a gold-catalyzed cycloisomerization followed by a Sc(OTf)<sub>3</sub>-catalyzed [3+2] cycloaddition with bicyclo[1.1.0]butanes (BCBs) in less than 1 h.
Authors
- Yunjie Zhu
- Zhenghu Xu (ORCID: https://orcid.org/0000-0002-3189-0777)
- Yangdong Hou
Institutions
- Shandong University (CN)
- Interface (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c01542
- Citations
- 4
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.74
Funders
- National Natural Science Foundation of China