Assembly of 1,2,3‐Triazole‐Fused Polycyclic Compounds by Palladium‐Catalyzed CH Bond Activation
A palladium‐catalyzed protocol for the synthesis of 1,2,3‐triazole‐fused heterocycles, such as 1,4,5,6‐tetrahydrobenzo[ c ][1,2,3]triazolo[4,5‐ e ]azepines and 4,6‐dihydro‐1 H ‐benzo[5,6]oxepino[3,4‐ d ][1,2,3]triazoles, is reported. The method is versatile, high yielding, and even suitable for domino and one‐pot sequential protocols, combining the copper‐catalyzed reaction of alkynes and organic azides (CuAAC) with palladium‐catalyzed CH bond activation. A plausible reaction mechanism is proposed.
Authors
- Federico Marrone (ORCID: https://orcid.org/0000-0003-2350-639X)
- Antonella Goggiamani (ORCID: https://orcid.org/0000-0001-8339-4284)
- Antonia Iazzetti (ORCID: https://orcid.org/0000-0002-7792-774X)
- Andrea Serafini
- Karim Ullah (ORCID: https://orcid.org/0000-0003-0360-8903)
- Yuri Gazzilli
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Teramo (IT)
- Agostino Gemelli University Polyclinic (IT)
- Sapienza University of Rome (IT)
- KU Leuven (BE)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1002/ejoc.202500459
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00