Formulation, Development and Evaluation of ExtendedRelease Tablets of Fenbendazole

This study aimed to formulate, develop, and evaluate extended-release tablets of Fenbendazole using various polymers, including Hydroxypropyl Methylcellulose K15 (HPMC K15), Ethyl Cellulose, and Tragacanth. The objective was to enhance the sustained release profile of Fenbendazole while ensuring compliance with the Indian Pharmacopoeia (IP) limits for both pre-compression and post-compression parameters. Different formulations were prepared by the direct compression technique, and their physical characteristics, such as hardness, friability, weight variation, and thickness, were assessed. Additionally, drug content uniformity, in vitro dissolution studies, and evaluations were conducted. The results showed that all formulations met the IP specifications for pre-compression and post-compression parameters. Among the various formulations, the one containing a combination of HPMC K15, Ethyl Cellulose, and Tragacanth demonstrated an optimal drug release profile, with a cumulative drug release of 99.56% at the 12-hour mark (F6 formulation). This formulation displayed a highly satisfactory release pattern, making it the most optimized among all tested formulations. The study concludes that the F6 formulation offers a promising extended-release system for Fenbendazole with sustained therapeutic effects over an extended period, meeting the necessary Pharmacopoeial standards for oral drug delivery systems.