Open-label pilot study using hydroxytyrosol as dietary supplements in patients with mitochondrial diseases
This study highlights the use of HT as a health supplement and its potential therapeutic effects in paediatric patients diagnosed with MDs, especially in MELAS patients. The results lay the foundation for future large-scale clinical trials. Consequently, further clinical intervention studies and investigations into HT's potential therapeutic mechanisms at the molecular and intercellular levels are strongly encouraged.
Authors
- Vivian Kwok
- Toby Chun Hei Chan (ORCID: https://orcid.org/0000-0001-9099-4720)
- SP Lam
- Theodoric Wong (ORCID: https://orcid.org/0000-0003-1360-5175)
- Kiran Belaramani (ORCID: https://orcid.org/0000-0003-1037-7541)
- Yee Ling Elaine Kan (ORCID: https://orcid.org/0000-0002-6839-6000)
- Suet Na Wong
- Emily Man
- Paul P. Lau
- Kai Tai Derek Yeung (ORCID: https://orcid.org/0000-0002-5679-9435)
- Ken Wong
- Patricio E. Lau (ORCID: https://orcid.org/0000-0003-2529-8942)
- Freddie Man Hong Poon
- Vanessa Chu
- Monika Mak (ORCID: https://orcid.org/0000-0002-0565-2011)
- Cheuk Wing Fung (ORCID: https://orcid.org/0000-0002-0105-1673)
- Kevin Hak Kong Yip
- Hui Zhi (ORCID: https://orcid.org/0000-0001-6008-1541)
- Carmen W.H. Chan (ORCID: https://orcid.org/0000-0003-0696-2369)
- Ian Chi Kei Wong (ORCID: https://orcid.org/0000-0001-8242-0014)
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Chunquan Li (ORCID: https://orcid.org/0000-0002-4700-5496)
- Anna Ka Yee Kwong
- Anne Mei Kwun Kwok (ORCID: https://orcid.org/0000-0002-3995-6718)
Institutions
- Department of Health (CN)
- Chinese University of Hong Kong (HK)
- Duchess of Kent Children's Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s13023-025-03795-0
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Health and Medical Research Fund