Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation
Promoting educational attainment, maintaining favorable serum urate, and controlling obesity are specifically prioritized for CMM prevention. Furthermore, avoiding smoking and sedentary behavior, and strengthening physical activity held prominent protective impacts on CMDs. Additionally, improving dyslipidemia and dysglycemia, maintaining favorable blood pressure, and enhancing lung function, would contribute to the co-management of CMDs and preventing the long-term CMM condition. Our investigation provided causality-oriented evidence to establish the risk profile of CMM.
Authors
- Li Sun (ORCID: https://orcid.org/0000-0002-8211-6124)
- Yujian Li (ORCID: https://orcid.org/0000-0002-6318-9782)
- Lihui Zhou (ORCID: https://orcid.org/0000-0002-4639-264X)
- Weili Xu (ORCID: https://orcid.org/0000-0001-6140-2968)
- Dun Li (ORCID: https://orcid.org/0000-0002-1986-7144)
- Jing Lin (ORCID: https://orcid.org/0000-0002-7458-6820)
- Hongxi Yang (ORCID: https://orcid.org/0000-0002-9545-5715)
- Yaogang Wang
- Xinyu Zhang (ORCID: https://orcid.org/0000-0002-7046-2783)
- Zhe Xu (ORCID: https://orcid.org/0000-0002-9705-8924)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Karolinska Institutet (SE)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s12933-025-02790-w
- Citations
- 9
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 16.36
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project