Preclinical evaluation of glycan-targeting monoclonal antibodies for bimodal near-infrared fluorescence and photoacoustic imaging of gastrointestinal cancers
Bimodal NIRF/PA imaging employing CH88.2-800CW and CH129-800CW facilitates real-time, high-contrast gastrointestinal tumor visualization. Given their strong and mostly tumor-specific expression, both tracers hold promise as effective imaging agents for gastrointestinal cancers, and are compelling candidates for further clinical evaluation.
Authors
- Jia Xin Chua (ORCID: https://orcid.org/0000-0002-1035-0480)
- Victor M. Baart (ORCID: https://orcid.org/0000-0003-3583-7428)
- Maurice van Duijvenvoorde
- Vincent Q. Sier (ORCID: https://orcid.org/0000-0003-3463-1217)
- J. Sven D. Mieog (ORCID: https://orcid.org/0000-0002-3649-8504)
- Alexander L. Vahrmeijer (ORCID: https://orcid.org/0000-0001-9370-0011)
- Gerardus J. Hassing (ORCID: https://orcid.org/0000-0002-7979-3546)
- Timo Schomann (ORCID: https://orcid.org/0000-0002-0948-6209)
- Mireille Vankemmelbeke (ORCID: https://orcid.org/0000-0002-8100-813X)
- Pieter de Heer (ORCID: https://orcid.org/0000-0002-2874-2319)
- Peter J.K. Kuppen (ORCID: https://orcid.org/0000-0002-0294-3251)
- Daniëlle Krijgsman (ORCID: https://orcid.org/0000-0001-6101-7146)
- Ruben D. Houvast (ORCID: https://orcid.org/0000-0002-8813-0330)
- Jacobus Burggraaf (ORCID: https://orcid.org/0000-0001-7912-0918)
- Lindy G. Durrant (ORCID: https://orcid.org/0000-0002-7217-3707)
- A. Stijn L. P. Crobach
Institutions
- University of Nottingham (GB)
- Leiden University Medical Center (NL)
- Rigshospitalet (DK)
- University Medical Center Utrecht (NL)
- Centre for Human Drug Research (NL)
- Center for Translational Molecular Medicine (NL)
- Western Digital (Netherlands) (NL)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s13550-025-01258-y
- Citations
- 2
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61