Sustained Metabolic Improvements with Low-Dose Metformin Combined with Oral Contraceptives in Female Adolescents with PCOS: A Single-Center Retrospective Cohort Study
Our study highlights the effectiveness of low-dose metformin therapy in improving insulin resistance and metabolic parameters among adolescent patients with PCOS. Sustained benefits were observed even after treatment cessation. These findings underscore the potential for early intervention with metformin during adolescence to confer long-lasting advantages in managing metabolic abnormalities associated with PCOS.
Authors
- Anna Maria Fulghesu (ORCID: https://orcid.org/0000-0001-8116-3968)
- Stefano Angioni (ORCID: https://orcid.org/0000-0002-2314-0028)
- Alice Tassi (ORCID: https://orcid.org/0000-0003-0249-6284)
- Stefano Di Michele (ORCID: https://orcid.org/0009-0005-9644-7919)
- Claudia Succu (ORCID: https://orcid.org/0000-0002-3843-5064)
- Salvatore Giovanni Vitale
Institutions
- University of Cagliari (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
Publication Details
- Journal
- Advances in Therapy
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1007/s12325-025-03251-2
- Citations
- 7
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 11.89