Intravenous Glyburide in Medical and Endovascular‐Treated Large‐Core Stroke: A Subgroup Analysis of the <scp>CHARM</scp> Randomized Clinical Trial
This post-hoc analysis of the CHARM trial provides hypothesis-generating evidence that i.v. glyburide may improve outcome in large-core stroke <125 ml, especially among endovascular thrombectomy-treated patients. These results require confirmation in a prospective randomized clinical trial. ANN NEUROL 2025;98:616-624.
Authors
- Stephen Bacchi (ORCID: https://orcid.org/0000-0001-5130-8628)
- Holly E. Hinson (ORCID: https://orcid.org/0000-0003-1598-9782)
- Ḱazunori Toyoda (ORCID: https://orcid.org/0000-0002-8346-9845)
- Gregory W. Albers (ORCID: https://orcid.org/0000-0003-0263-4632)
- Marcelo Borges Rocha (ORCID: https://orcid.org/0000-0003-4472-7423)
- Max Wintermark (ORCID: https://orcid.org/0000-0002-6726-3951)
- Kevin Navin Sheth (ORCID: https://orcid.org/0000-0003-2003-5473)
- Bradley J. Molyneaux (ORCID: https://orcid.org/0000-0002-3377-1229)
- Sven Jacobson
- J. Marc Simard (ORCID: https://orcid.org/0000-0002-5373-1988)
- Bruce C.V. Campbell (ORCID: https://orcid.org/0000-0003-3632-9433)
- Charlotte Cordonnier (ORCID: https://orcid.org/0000-0002-5697-6892)
- Jeffrey L. Saver (ORCID: https://orcid.org/0000-0001-9141-2251)
- Raul G. Nogueira (ORCID: https://orcid.org/0000-0003-4532-153X)
- Shilpi Mittal (ORCID: https://orcid.org/0000-0001-8482-0599)
- W. Taylor Kimberly (ORCID: https://orcid.org/0000-0002-2519-8530)
- Gagan Sharma (ORCID: https://orcid.org/0009-0009-3427-0897)
- Thorsten Steiner
Institutions
- Goethe University Frankfurt (DE)
- University of Maryland, Baltimore (US)
- Brigham and Women's Hospital (US)
- The Royal Melbourne Hospital (AU)
- The University of Texas MD Anderson Cancer Center (US)
- Thomas Jefferson University (US)
- Inserm (FR)
- University of California, Los Angeles (US)
- The University of Melbourne (AU)
- University of California, San Francisco (US)
- Heidelberg University (DE)
- Université de Lille (FR)
- University Hospital Heidelberg (DE)
- Centre Hospitalier Universitaire de Lille (FR)
- Yale University (US)
- Massachusetts General Hospital (US)
- Immune Pharmaceuticals (United States) (US)
- Stanford Health Care (US)
- National Cerebral and Cardiovascular Center (JP)
- Yale New Haven Health System (US)
- University Hospital Frankfurt (DE)
- University of Pittsburgh Medical Center (US)
- Stanford Medicine (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1002/ana.27268
- Citations
- 3
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Biogen
- National Institute of Neurological Disorders and Stroke