Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity
The expansion of the Tox21 assay panel has significantly enhanced the predictive capacity of assay data for predicting DILI and DICT potential. This improvement underscores the importance of a diverse and comprehensive <i>in vitro</i> assay portfolio in advancing safety assessment. https://doi.org/10.1289/EHP16190.
Authors
- Deborah K. Ngan
- Jameson Travers (ORCID: https://orcid.org/0000-0002-4861-7988)
- Ruili Huang (ORCID: https://orcid.org/0000-0001-8886-8311)
- Carleen Maitland
- Tuan Xu (ORCID: https://orcid.org/0000-0001-6430-3500)
- Menghang Xia (ORCID: https://orcid.org/0000-0001-7285-8469)
- Tongan Zhao
- Anton Simeonov (ORCID: https://orcid.org/0000-0002-4523-9977)
- Srilatha Sakamuru (ORCID: https://orcid.org/0000-0002-9693-1832)
- David M. Reif (ORCID: https://orcid.org/0000-0001-7815-6767)
- Masato Ooka (ORCID: https://orcid.org/0000-0002-2729-2619)
- Natalie D. Shaw (ORCID: https://orcid.org/0000-0002-0847-9170)
- Li Zhang (ORCID: https://orcid.org/0000-0002-9386-8938)
- Jinghua Zhao (ORCID: https://orcid.org/0000-0001-7415-1619)
- Shu Yang (ORCID: https://orcid.org/0000-0003-4755-5348)
- Hu Zhu
- Stephen Ferguson (ORCID: https://orcid.org/0000-0003-3172-8347)
- Mathew D. Hall
Institutions
- National Institutes of Health (US)
- National Institute of Environmental Health Sciences (US)
- Orszagos Kornyezetegeszsegugyi Intezet (HU)
- National Center for Advancing Translational Sciences (US)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1289/ehp16190
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences