Microbiome gut community structure and functionality are associated with symptom severity in non-responsive celiac disease patients undergoing a gluten-free diet
Celiac disease (CD) is a chronic immune-mediated systemic disorder caused by consuming gluten in genetically susceptible individuals. There is currently no cure for CD, and the most effective treatment is maintaining a strict, lifelong gluten-free diet (GFD). This nutritional therapy aims to prevent the immune reaction triggered by gluten and promote the healing of the intestinal lining, resolving the clinical, serological, and histological abnormalities within 6-12 months. However, up to 30% of patients may continue to experience symptoms or exhibit laboratory abnormalities or intestinal inflammation suggestive of active CD, despite following a GFD. This challenge, which encompasses various diagnoses, is known as nonresponsive celiac disease (NRCD). In this study, we explored the role of intestinal microbiota in causing NRCD, finding an association between the persistence of symptoms and changes in mucosal integrity biomarkers, with different gut microbiome structures among NRCD patients, indicating a significant role of the microbiome in NRCD.
Authors
- Enrique Carrillo de Santa Pau (ORCID: https://orcid.org/0000-0002-2310-2267)
- Helena Marcos-Pasero (ORCID: https://orcid.org/0000-0002-6123-8798)
- Alberto Valdés (ORCID: https://orcid.org/0000-0002-7901-5816)
- Elena Aguilar-Aguilar (ORCID: https://orcid.org/0000-0001-9044-5633)
- Alejandro Cifuentes (ORCID: https://orcid.org/0000-0002-7464-0217)
- Blanca Lacruz-Pleguezuelos (ORCID: https://orcid.org/0000-0003-3786-7233)
- Véra Pancaldi (ORCID: https://orcid.org/0000-0002-7433-624X)
- Ana Ramı́rez de Molina (ORCID: https://orcid.org/0000-0003-1439-7494)
- Alberto Díaz‐Ruiz (ORCID: https://orcid.org/0000-0002-0488-4216)
- Laura Judith Marcos-Zambrano (ORCID: https://orcid.org/0000-0003-1381-6407)
Institutions
- Madrid Institute for Advanced Studies (ES)
- Universidad Complutense de Madrid (ES)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Centre de Recherches en Cancérologie de Toulouse (FR)
- Universidad Europea (MX)
- IMDEA Food (ES)
- Instituto de Investigación en Ciencias de la Alimentación (ES)
- Universidad Autónoma de Madrid (ES)
- Universidad Europea de Madrid (ES)
Publication Details
- Journal
- mSystems
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1128/msystems.00143-25
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Comunidad de Madrid
- European Commission
- European Society of Clinical Microbiology and Infectious Diseases
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación