Vascular Calcification Amplifies Limb Flexion-Induced Arterial Deformations and Causes Intermittent Vessel Pinching
Arterial calcification significantly amplifies limb flexion-induced deformations, leading to sharper bending, greater lumen narrowing, and increased risk of intermittent flow obstruction. These findings highlight the importance of bent-leg imaging to identify high-risk arterial segments and guide targeted interventions, such as plaque modification or stent designs optimized to mitigate arterial kinking.
Authors
- Alexey Kamenskiy (ORCID: https://orcid.org/0000-0003-4887-2660)
- Yuqian Tian (ORCID: https://orcid.org/0000-0002-4279-190X)
- Donald F. Orton
- Jason MacTaggart (ORCID: https://orcid.org/0000-0003-1204-699X)
- Iraklis I. Pipinos (ORCID: https://orcid.org/0000-0001-6873-6346)
- M. Beatriz P.P. Oliveira (ORCID: https://orcid.org/0000-0002-6767-6596)
- Xiaozhou Liu (ORCID: https://orcid.org/0000-0002-3653-398X)
Institutions
- University of Nebraska at Omaha (US)
- VA Nebraska Western Iowa Health Care System (US)
- Alexion Pharma (Switzerland) (CH)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Annals of Surgery
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1097/sla.0000000000006776
- Citations
- 4
- Primary Topic
- Peripheral Artery Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 8.03