Dielectric Barrier Discharge Plasma Combined With Iontophoresis to Enhance Transdermal Drug Delivery Efficiency

ABSTRACT Cold atmospheric plasma holds significant promise for transdermal drug delivery (TDD) due to its physicochemical effects, including reactive species and electroporation. Herein, dielectric barrier discharge plasma was used to enhance TDD efficiency. The results demonstrated that plasma significantly increases skin permeability, exhibiting a biphasic response to treatment duration, with the diclofenac sodium penetration efficiency increased by four times at the optimal dose of 20 min. Histological analysis revealed that plasma induces reversible skin barrier disruption, providing a critical therapeutic window for TDD. Moreover, iontophoresis was applied following plasma treatment to enhance drug permeation, leading to a sixfold increase in diclofenac sodium penetration efficiency. Therefore, plasma combined with iontophoresis provides a safe and effective strategy for clinal TDD application.

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Publication Details

Journal
Plasma Processes and Polymers
Published
2025-06-06
DOI
https://doi.org/10.1002/ppap.70044
Citations
1
Primary Topic
Advancements in Transdermal Drug Delivery
Type
article
Field-Weighted Citation Impact
0.79

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article

Dielectric Barrier Discharge Plasma Combined With Iontophoresis to Enhance Transdermal Drug Delivery Efficiency

Shiyao Wang, Dingxin Liu, Jishen Zhang, Xixi Jing et al.
1 citations
Plasma Processes and Polymers
Advancements in Transdermal Drug Delivery
0.79
article

Dielectric Barrier Discharge Plasma Combined With Iontophoresis to Enhance Transdermal Drug Delivery Efficiency

Shiyao Wang, Dingxin Liu, Jishen Zhang, Xixi Jing, Mingzhe Rong, Zifeng Wang, Wei Wei, Chang Liu, Hao Zhang, Xiaohua Wang, Qi Chang, Jingyao Zhang, Zewei Wang
article en
1 citations

Abstract

ABSTRACT Cold atmospheric plasma holds significant promise for transdermal drug delivery (TDD) due to its physicochemical effects, including reactive species and electroporation. Herein, dielectric barrier discharge plasma was used to enhance TDD efficiency. The results demonstrated that plasma significantly increases skin permeability, exhibiting a biphasic response to treatment duration, with the diclofenac sodium penetration efficiency increased by four times at the optimal dose of 20 min. Histological analysis revealed that plasma induces reversible skin barrier disruption, providing a critical therapeutic window for TDD. Moreover, iontophoresis was applied following plasma treatment to enhance drug permeation, leading to a sixfold increase in diclofenac sodium penetration efficiency. Therefore, plasma combined with iontophoresis provides a safe and effective strategy for clinal TDD application.

Plasma Processes and PolymersVol. 22(8)
People's Liberation Army No. 150 Hospital (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Xi'an Jiaotong University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 27%
Advancements in Transdermal Drug Delivery
0.79
DOIOpen Access PDFOpenAlex
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