Bifidobacterium longum subsp. longum dipro-O: a potential therapeutic agent for ameliorating metabolic disorders in high-fat diet-induced obesity mouse model
Dipro-O effectively reduced HFD-induced obesity by decreasing body weight gain, serum lipid marker levels, and liver fat accumulation. QPCR and 16S rRNA sequencing data indicated that dipro-O intervention promoted intestinal homeostasis maintenance. Taken together, these findings indicate that dipro-O has the potential to intervene in lipid disorders as an alternative to drug therapies.
Authors
- Weiyang Chen (ORCID: https://orcid.org/0000-0001-8430-7381)
- Mei‐Ru Chen (ORCID: https://orcid.org/0000-0002-7007-8036)
- Qinghua Yu (ORCID: https://orcid.org/0000-0002-0590-1356)
- Junlin Wu (ORCID: https://orcid.org/0009-0006-1037-1827)
- Yanqing Hao
- Ning Xu (ORCID: https://orcid.org/0000-0001-7909-7025)
- Weiwei Xiang
- Yue Zhai (ORCID: https://orcid.org/0000-0002-9733-7042)
- Luo J (ORCID: https://orcid.org/0009-0006-0570-7509)
- Wei Jiang (ORCID: https://orcid.org/0000-0002-4697-6522)
Institutions
- SAIC-GM (China) (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fendo.2025.1519058
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81