Immunization with Inactivated Bacillus subtilis Spores Expressing TonB-Dependent Receptor (TBDR) Protects Against Multidrug-Resistant Acinetobacter baumannii Infection
These findings demonstrate that inactivated <i>B. subtilis</i> spores expressing TBDR are a safe, orally administrable vaccine platform that elicits protective immunity against MDR <i>A. baumannii</i>. By addressing biosafety concerns associated with live spores while maintaining efficacy, this approach represents a critical advance toward preventing high-risk nosocomial infections.
Authors
- Amalia A. Saperi (ORCID: https://orcid.org/0000-0003-3869-2383)
- Anna Hazan
- Nurfatihah Zulkifli (ORCID: https://orcid.org/0000-0003-3579-7171)
- NorAziyah MatRahim (ORCID: https://orcid.org/0000-0001-5953-2886)
- Hai Yen Lee (ORCID: https://orcid.org/0000-0001-6322-6718)
- Sazaly AbuBakar (ORCID: https://orcid.org/0000-0002-9267-1420)
Institutions
- University Malaya Medical Centre (MY)
- Institute for Medical Research (MY)
- Universiti Teknologi MARA System (MY)
Publication Details
- Journal
- Vaccines
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3390/vaccines13060616
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.36
Funders
- Ministry of Higher Education, Malaysia