Quantum AI for Alzheimer’s disease early screening

Quantum machine learning is a new research field combining quantum information science and machine learning. Quantum computing technologies appear to be particularly well-suited for addressing problems in the health sector efficiently. They have the potential to handle large datasets more effectively than classical models and offer greater transparency and interpretability for clinicians. Alzheimer’s disease is a neurodegenerative brain disorder that mostly affects elderly people, causing important cognitive impairments. It is the most common cause of dementia and it has an effect on memory, thought, learning abilities and movement control. This type of disease has no cure, consequently an early diagnosis is fundamental for reducing its impact. The analysis of handwriting can be effective for diagnosing, as many researches have conjectured. The DARWIN (Diagnosis AlzheimeR WIth haNdwriting) dataset contains handwriting samples from people affected by Alzheimer’s disease and a group of healthy people. Here we apply quantum AI to this use-case. In particular, we use this dataset to test classical methods for classification and compare their performances with the ones obtained via quantum machine learning methods. We find that quantum methods generally perform better than classical methods. Our results pave the way for future new quantum machine learning applications in early-screening diagnostics in the healthcare domain.

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Publication Details

Journal
Neurocomputing
Published
2025-06-06
DOI
https://doi.org/10.1016/j.neucom.2025.130565
Citations
3
Primary Topic
Quantum Computing Algorithms and Architecture
Type
article
Field-Weighted Citation Impact
7.44

Funders

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article

Quantum AI for Alzheimer’s disease early screening

G. Cappiello, F. L. Caruso
3 citations
Neurocomputing
Quantum Computing Algorithms and Architecture
7.44
article

Quantum AI for Alzheimer’s disease early screening

G. Cappiello, F. L. Caruso
article en
3 citations

Abstract

Quantum machine learning is a new research field combining quantum information science and machine learning. Quantum computing technologies appear to be particularly well-suited for addressing problems in the health sector efficiently. They have the potential to handle large datasets more effectively than classical models and offer greater transparency and interpretability for clinicians. Alzheimer’s disease is a neurodegenerative brain disorder that mostly affects elderly people, causing important cognitive impairments. It is the most common cause of dementia and it has an effect on memory, thought, learning abilities and movement control. This type of disease has no cure, consequently an early diagnosis is fundamental for reducing its impact. The analysis of handwriting can be effective for diagnosing, as many researches have conjectured. The DARWIN (Diagnosis AlzheimeR WIth haNdwriting) dataset contains handwriting samples from people affected by Alzheimer’s disease and a group of healthy people. Here we apply quantum AI to this use-case. In particular, we use this dataset to test classical methods for classification and compare their performances with the ones obtained via quantum machine learning methods. We find that quantum methods generally perform better than classical methods. Our results pave the way for future new quantum machine learning applications in early-screening diagnostics in the healthcare domain.

NeurocomputingVol. 647
Nello Carrara Institute of Applied Physics (IT), National Institute of Optics (IT), Istituto Nazionale di Fisica Nucleare, Sezione di Firenze (IT), University of Florence (IT)
European Defence Agency, European Commission, Ministero dell'Università e della Ricerca, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Horizon 2020
Openalex Percentile: Top 3%
Quantum Computing Algorithms and Architecture
7.44
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Quantum AI for Alzheimer’s disease early screening — G. Cappiello, F. L. Caruso · Neurocomputing (2025) | TGRS Research Map | TGRS