Glycolytic control proteins in urinary extracellular vesicles are elevated during kidney transplant T cell-mediated rejection
Increased rate-limiting enzymes of glycolysis in UEV were detected in association with tubulointerstitial inflammation and fibrosis. This suggests altered energy metabolism in the form of increased renal glycolysis occurring in the tubular epithelium, consistent with findings in native kidney injury. Further work is required to evaluate whether this could serve as a non-invasive strategy to study pathology in kidney transplantation.
Authors
- Peter F. Mount (ORCID: https://orcid.org/0000-0001-7637-3661)
- David A. Power (ORCID: https://orcid.org/0000-0003-3983-0581)
- Marina Katerelos
- John B. Whitlam (ORCID: https://orcid.org/0000-0003-2202-1462)
- Alison Graver (ORCID: https://orcid.org/0000-0001-7585-0403)
- Po Yee Mia Leung (ORCID: https://orcid.org/0000-0002-3736-0777)
- Alison Skene
Institutions
- The University of Melbourne (AU)
- Melbourne Health (AU)
- Austin Health (AU)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s12882-025-04196-y
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00