Comparative analysis of isoxazoline activity on human and canine GABA receptors expressed in Xenopus oocytes

While neurological adverse events have been reported in dogs, particularly in breeds with the multidrug resistance 1 (MDR1) gene mutation, this study suggests that direct inhibition of canine GABARs may not be the primary cause. However, the interpretation of these results represents a challenge, and a direct correlation with documented cases of adverse events remains difficult. Further research is needed to understand the exposure of mammalian GABARs to isoxazolines and the analog-specific safety risks associated with the observed in vitro receptor activities.