Systemic Inflammation and the Risks of Adverse Kidney Outcomes in Adults With Atherosclerotic Cardiovascular Disease
Inconsistent evidence exists regarding the association between the circulating blood marker of inflammation C-reactive protein (CRP) and kidney outcomes. We conducted an observational study in more than 83,000 adults with atherosclerotic cardiovascular disease undergoing routine care. The study showed that CRP levels were higher in participants with lower levels of kidney function and that CRP was associated with more rapid declines in kidney function over time as well as a greater risk of acute kidney injury.
Authors
- Edouard L. Fu (ORCID: https://orcid.org/0000-0002-9698-6825)
- Katherine R. Tuttle (ORCID: https://orcid.org/0000-0002-2235-0103)
- Juan Jesús Carrero (ORCID: https://orcid.org/0000-0003-4763-2024)
- Oscar Plunde (ORCID: https://orcid.org/0000-0003-1343-2198)
- Faizan Mazhar (ORCID: https://orcid.org/0000-0002-2818-1179)
- Paul Hjemdahl (ORCID: https://orcid.org/0000-0001-5346-275X)
- Jimmi Mathisen (ORCID: https://orcid.org/0000-0002-7391-7296)
- Iram Faqir Muhammad (ORCID: https://orcid.org/0000-0002-4026-3302)
- Vlado Perkovic
- Anne-Laure Faucon
Institutions
- Karolinska University Hospital (SE)
- Novo Nordisk (Denmark) (DK)
- Leiden University Medical Center (NL)
- Inland Northwest Health Services (US)
- Danderyds sjukhus (SE)
- Karolinska Institutet (SE)
- UNSW Sydney (AU)
- The George Institute for Global Health (AU)
Publication Details
- Journal
- American Journal of Kidney Diseases
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1053/j.ajkd.2025.04.011
- Citations
- 2
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59