Light Influences Time-of-Day Differences in the Expression of Clock Genes and Redox Genes Involved in Glutathione Homeostasis in the Lens
The lens possesses the ability to detect light via melanopsin localized exclusively in the anterior lens epithelium. This may act as a cue for the lens to drive day and night differences in the expression of clock genes and/or redox genes, ensuring that GSH levels are maintained at normal physiological levels to provide protection from oxidative stress across the light/dark cycle.
Authors
- Paul J. Donaldson (ORCID: https://orcid.org/0000-0002-4008-1138)
- Renita M. Martis (ORCID: https://orcid.org/0000-0002-8143-2563)
- Haruna Suzuki‐Kerr (ORCID: https://orcid.org/0000-0002-4860-3527)
- Raewyn C. Poulsen (ORCID: https://orcid.org/0000-0002-3788-6410)
- Fan Yang (ORCID: https://orcid.org/0000-0002-0841-8933)
- Julie C. Lim (ORCID: https://orcid.org/0000-0002-6307-7297)
- Christopher J. J. Lim
- Бо Ли (ORCID: https://orcid.org/0000-0002-8019-8891)
- Erl Carlos
Institutions
- University of Auckland (NZ)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1167/iovs.66.6.24
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91