Wharton’s jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway
In conclusions, our findings indicated that WJMSCs infusions may enhance M2 macrophage polarization through the COX2-PGE2 pathway, and therefore safeguard against cardiac damage in HAHI mice.
Authors
- Ningkun Zhang (ORCID: https://orcid.org/0009-0004-9015-0420)
- Li Yang (ORCID: https://orcid.org/0000-0003-0640-2003)
- Dongtao Li
- Jing Cui (ORCID: https://orcid.org/0000-0002-7664-4780)
- Zhibo Hong
- Shan Wang (ORCID: https://orcid.org/0000-0002-6912-1949)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-4121-4331)
- Jiamin Liu (ORCID: https://orcid.org/0009-0008-2003-2786)
- Yu Chen (ORCID: https://orcid.org/0009-0008-7166-2665)
- Li Zhao (ORCID: https://orcid.org/0009-0006-0022-5973)
- Wenhong Zhang
Institutions
- Anhui Medical University (CN)
- Chinese PLA General Hospital (CN)
- 307th Hospital of Chinese People’s Liberation Army (CN)
- Beijing Anzhen Hospital (CN)
- Beijing Institute of Water (CN)
- The 309th Hospital of Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1538046
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 3.25
Funders
- Natural Science Foundation of Beijing Municipality
- National Key Research and Development Program of China