Causal associations between air pollution and breast cancer risk and survival: a Mendelian randomization study
This study provides evidence of a causal link between long-term exposure to NO₂ and PM<sub>10</sub> and breast cancer risk, especially for hormone receptor subtypes. However, the effects of PM<sub>2.5</sub> and NO<sub>x</sub> on breast cancer risk were not significant, and air pollution exposure did not appear to impact survival. Further research is needed to elucidate the specific biological mechanisms and to extend the analysis to non-European populations.
Authors
- Wenhuan Li (ORCID: https://orcid.org/0000-0002-8121-7521)
- Lin Chen (ORCID: https://orcid.org/0000-0003-3399-8711)
- Bo Hu (ORCID: https://orcid.org/0000-0002-4465-9814)
- Yonggang Yang
- Pengfei Shi (ORCID: https://orcid.org/0000-0002-7692-4627)
- Xinyu Su (ORCID: https://orcid.org/0000-0003-4479-0078)
- Rong Xie
Institutions
- Central Hospital of Wuhan (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1007/s12672-025-02874-9
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Hubei Province
- China Primary Health Care Foundation