Diffusion tensor imaging of sequential neuropathological patterns in progressive supranuclear palsy
The combined ROI- and TOI-based DTI approach was able to map the disease stages of PSP <i>in vivo</i> cross-sectionally and longitudinally, lending support to DTI as a technical marker for imaging disease progression according to PSP stages. This approach might be useful as a tool for stratification of PSP patients MRI with respect to its proposed neuropathological progression in future longitudinal and autopsy-controlled studies.
Authors
- Albert C. Ludolph (ORCID: https://orcid.org/0000-0002-5401-0904)
- Heiko Braak (ORCID: https://orcid.org/0000-0002-6776-1045)
- Kelly Del Tredici (ORCID: https://orcid.org/0000-0002-9130-7838)
- Lavinia A. Bârlescu
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Jan Kassubek (ORCID: https://orcid.org/0000-0002-7106-9270)
- Hans-Peter Müller
- Heiko Volkmann
Institutions
- Universität Ulm (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Munich Cluster for Systems Neurology (DE)
- University Hospital Ulm (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-06-06
- DOI
- https://doi.org/10.3389/fnagi.2025.1569302
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Deutsches Zentrum für Neurodegenerative Erkrankungen