Targeting PTGDS inhibits pro-inflammatory fibroblasts associated with skin fibrosis in systemic sclerosis
PTGDS-induced pro-inflammatory fibroblasts caused Th2 cell infiltration and skin fibrosis. Inhibition of PTGDS attenuated the inflammation and fibrosis in the skin. These results demonstrate that PTGDS is a critical regulator of the pro-inflammatory function of skin fibroblasts, providing a promising therapeutic target for SSc.
Authors
- Li Zhao (ORCID: https://orcid.org/0000-0001-7374-3348)
- Jinlin Wang (ORCID: https://orcid.org/0009-0008-1010-5195)
- Rong Mu (ORCID: https://orcid.org/0000-0001-6846-3659)
- Xiandun Yuan
- Xiaoyu Li (ORCID: https://orcid.org/0009-0006-9840-6704)
- Wei Guo (ORCID: https://orcid.org/0000-0002-1923-6975)
- Dan Fang (ORCID: https://orcid.org/0009-0004-5434-3997)
- Jingkun Yi (ORCID: https://orcid.org/0000-0003-0675-8456)
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1093/rheumatology/keaf276
- Citations
- 2
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.94