Retinal changes in children with Familial Mediterranean Fever: the effect of chronic subclinical inflammation

This study assessed peripapillary RNFL thickness and choroidal vascular structure in children with FMF using SD-OCT to evaluate ocular effects of subclinical inflammation. It was found that chronic inflammation may lead to thinning of the retina and choroid even in children with relatively short disease duration. Peripapillary RNFL thickness was reduced in the temporal inferior quadrant and correlated with serum amyloid levels; additionally, choroidal thickness was significantly lower in the patient group, suggesting early ocular involvement and its potential as a marker of subclinical systemic inflammation.