Screening and validation of 3’-Methoxydaidzein as a therapeutic agent in ulcerative colitis based on disulfidptosis-associated molecular clusters
DRGs demonstrate strong discriminatory power in distinguishing UC subtypes. Cluster with high expression of SLC26A2 showed a UC phenotype with a milder degree of damage. Additionally, we identified the hub gene SLC26A2 as playing a significant role in UC, and MHD demonstrates potential as a targeted therapeutic strategy for UC.
Authors
- Chao Gao (ORCID: https://orcid.org/0000-0001-6652-5457)
- Jie Yuan (ORCID: https://orcid.org/0000-0003-4030-7472)
- Xin Wang (ORCID: https://orcid.org/0000-0001-8051-1481)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-5708-7878)
- Fanlin Meng
Institutions
- Army Medical University (CN)
- Xinqiao Hospital (CN)
- Sichuan Provincial Hospital of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1371/journal.pone.0324586
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00