Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats
This brain functional connectivity mapping illustrated a brain circuit composed of brain regions that are either a part of or connect with the mesolimbic reward pathway that is mediated by dopamine. When this circuit is dysregulated, it is believed to be associated with substance use disorders and reward dysregulation which have recently been described as attributes of preaddiction.
Authors
- Kenneth Blum (ORCID: https://orcid.org/0000-0001-6727-803X)
- Colin Hanna
- Rutao Yao (ORCID: https://orcid.org/0000-0002-5326-7644)
- Alireza Sharafshah (ORCID: https://orcid.org/0000-0001-8048-9587)
- Christopher G. Rowan (ORCID: https://orcid.org/0000-0002-4318-2970)
- Albert Pinhasov (ORCID: https://orcid.org/0000-0001-8116-4565)
- Kai‐Uwe Lewandrowski (ORCID: https://orcid.org/0000-0001-7842-2914)
- Panayotis K. Thanos (ORCID: https://orcid.org/0000-0001-9784-731X)
- Munawwar Sajjad
Institutions
- Eötvös Loránd University (HU)
- Guilan University of Medical Sciences (IR)
- Jacobs Institute (US)
- Ariel University (IL)
- University at Buffalo, State University of New York (US)
- Universidade Federal do Estado do Rio de Janeiro (BR)
- Western University of Health Sciences (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1371/journal.pone.0324522
- Citations
- 4
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 3.64