Glutathione-Depleting and Reactive Oxygen Species-Amplifying Upconversion Nanoplatform for Synergistic Ferroptosis

The overexpression of glutathione (GSH) in tumor cells neutralizes reactive oxygen species (ROS), thereby limiting oxidative stress-induced cell death. In this study, we develop a tumor-responsive upconversion nanoparticle (UCNPs)-based nanoplatform, UCNPs@mMnO2–Hypricin (UM-H), designed to deplete intracellular GSH and potentiate ROS-mediated antitumor therapy. The MnO2 shell selectively degrades in the presence of GSH, releasing Mn2+ ions, restoring UCNP luminescence, and serving as an indicator of GSH depletion. The released Mn2+ forms complexes with hypericin, enhancing ROS generation. Furthermore, Mn2+ catalyzes the Fenton reaction, generating hydroxyl radicals (·OH) to amplify oxidative damage, resulting in significant tumor suppression with minimal toxicity.

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Publication Details

Journal
ACS Applied Nano Materials
Published
2025-06-06
DOI
https://doi.org/10.1021/acsanm.5c02035
Citations
3
Primary Topic
Nanoplatforms for cancer theranostics
Type
article
Field-Weighted Citation Impact
2.02

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article

Glutathione-Depleting and Reactive Oxygen Species-Amplifying Upconversion Nanoplatform for Synergistic Ferroptosis

Fangfang Ke, Pengpeng Lei, Du Cheng, Zhen Zhang et al.
3 citations
ACS Applied Nano Materials
Nanoplatforms for cancer theranostics
2.02
article

Glutathione-Depleting and Reactive Oxygen Species-Amplifying Upconversion Nanoplatform for Synergistic Ferroptosis

Fangfang Ke, Pengpeng Lei, Du Cheng, Zhen Zhang, Yongming Chen, Shuyu Liu, Yilin Liu, Xiaoyu Ji, Kaimin Zhang, Weijia Huang, Nipeng Chen
article en
3 citations

Abstract

The overexpression of glutathione (GSH) in tumor cells neutralizes reactive oxygen species (ROS), thereby limiting oxidative stress-induced cell death. In this study, we develop a tumor-responsive upconversion nanoparticle (UCNPs)-based nanoplatform, UCNPs@mMnO2–Hypricin (UM-H), designed to deplete intracellular GSH and potentiate ROS-mediated antitumor therapy. The MnO2 shell selectively degrades in the presence of GSH, releasing Mn2+ ions, restoring UCNP luminescence, and serving as an indicator of GSH depletion. The released Mn2+ forms complexes with hypericin, enhancing ROS generation. Furthermore, Mn2+ catalyzes the Fenton reaction, generating hydroxyl radicals (·OH) to amplify oxidative damage, resulting in significant tumor suppression with minimal toxicity.

ACS Applied Nano MaterialsVol. 8(24)
Sun Yat-sen University (CN), Henan University (CN), Chinese Academy of Sciences (CN), Fudan University (CN), Changchun Institute of Applied Chemistry (CN), Division of Materials Science and Engineering (AU)
National Natural Science Foundation of China, Ministry of Science and Technology of the People's Republic of China, State Key Laboratory of Molecular Engineering of Polymers, Jilin Scientific and Technological Development Program
Openalex Percentile: Top 14%
Nanoplatforms for cancer theranostics
2.02
DOISourceOpenAlex
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Glutathione-Depleting and Reactive Oxygen Species-Amplifying Upconversion Nanoplatform for Synergistic Ferroptosis — Fangfang Ke, Pengpeng Lei, et al. · ACS Applied Nano Materials (2025) | TGRS Research Map | TGRS