Differential Expression of Toll-like Receptors and Antimicrobial Peptides in the Patients with Sézary Syndrome and Idiopathic Erythroderma

Erythroderma, characterized by the presence of erythematous patches and plaques affecting more than 80% of the body surface, is a manifestation of different cutaneous and systemic diseases [1]. Up to 20% of patients may remain undiagnosed thus characterizing Idiopathic Erythroderma (IE) [2]. Sézary Syndrome (SS) is an erythrodermic and leukemic variant of cutaneous T-cell lymphoma [3]. Moreover, sepsis from bacterial infections have been identified as a significant cause of mortality among these patients [4]. Toll-Like Receptors (TLRs) responsible for recognizing bacterial components (TLR2, TLR4, TLR5 and TLR9), along with the Antimicrobial Peptides (AMP), including Human Beta-Defensin (HBD) and Cathelicidins (CATH) play a significant role in the innate cutaneous immunity.