Initiation of ARB- vs ACEI-Based Antihypertensive Medication Regimens and Differences in Rates of Cognitive Decline
Previous research suggests that antihypertensive medications, such as angiotensin-II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs), can lower the risk of late-life cognitive decline and dementia. ACEIs and ARBs target distinct components of the renin-angiotensin system, which may differentially affect cognitive health. In this study, we aimed to evaluate the comparative effectiveness of initiating ARB-based vs ACEI-based antihypertensive therapy on differences in rates of cognitive change.
Authors
- Tom Greene (ORCID: https://orcid.org/0000-0002-3706-7570)
- Catherine G. Derington (ORCID: https://orcid.org/0000-0001-7382-4607)
- Zachary A. Marcum (ORCID: https://orcid.org/0000-0002-4690-2304)
- Yizhe Xu (ORCID: https://orcid.org/0000-0002-0773-1709)
- Daniel K. Addo (ORCID: https://orcid.org/0000-0002-3450-6718)
- Jeff D. Williamson (ORCID: https://orcid.org/0000-0002-0185-5823)
- Ransmond O. Berchie (ORCID: https://orcid.org/0000-0001-6883-6822)
- Nicholas M. Pajewski (ORCID: https://orcid.org/0000-0002-4447-6196)
- Jeremy J. Pruzin (ORCID: https://orcid.org/0000-0002-0443-4194)
- Ryan M. Andrews (ORCID: https://orcid.org/0000-0002-7750-2397)
- Adam P. Bress (ORCID: https://orcid.org/0000-0002-2259-5039)
- Mark A. Supiano (ORCID: https://orcid.org/0000-0002-5438-5087)
- Jordana B. Cohen (ORCID: https://orcid.org/0000-0003-4649-079X)
Institutions
- Intermountain Healthcare (US)
- Boston University (US)
- University of Washington (US)
- University of Utah (US)
- Banner Health (US)
- Banner Alzheimer’s Institute
- Wake Forest University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1212/wn9.0000000000000011
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00