Total Syntheses of Stereoisomeric Congeners of Rufomycin Natural Products Having Anti-Mycobacterial Activity
Syntheses of bioactive rufomycin natural product congeners that differ in stereochemistry at a conserved methyl-substituted amino-hydroxy-piperidone (Ahp) moiety have been achieved for the first time. In addition to gaining new insights into the formation and conformation of the Ahp stereoisomers, we were intrigued to find that theirs reduction improves rufomycin bioactivity significantly.
Authors
- Shichun Lun
- A. Andrew Pacheco (ORCID: https://orcid.org/0000-0002-2065-5624)
- Jason K. Sello (ORCID: https://orcid.org/0000-0001-6263-7902)
- William R. Bishai (ORCID: https://orcid.org/0000-0002-8734-4118)
- Fan Fei
Institutions
- Johns Hopkins University (US)
- University of California, San Francisco (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c01525
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Allergy and Infectious Diseases