Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer
Inhibition of mTOR induces ferritinophagy that increases free iron and stimulates ferroptosis, suggesting that this axis could be harnessed to help predict responses and to develop rational combination therapies to overcome resistance.
Authors
- Kuniaki Sato (ORCID: https://orcid.org/0000-0001-6014-1911)
- Pham Thuy Tien Vo (ORCID: https://orcid.org/0000-0001-5760-8461)
- J. Silvio Gutkind (ORCID: https://orcid.org/0000-0002-5150-4482)
- Edward A. Dennis (ORCID: https://orcid.org/0000-0003-3738-3140)
- Keiichi Koshizuka (ORCID: https://orcid.org/0000-0002-0431-8337)
- Gosia M. Murawska (ORCID: https://orcid.org/0000-0003-1822-9607)
- Alfredo Molinolo (ORCID: https://orcid.org/0000-0001-8412-2889)
- Tomohiko Ishikawa (ORCID: https://orcid.org/0000-0003-3115-0047)
- Zhiyong Wang
- Cherie‐Ann O. Nathan (ORCID: https://orcid.org/0000-0001-7386-318X)
- Xingyu Wu (ORCID: https://orcid.org/0000-0001-9289-7115)
- Prashant Mali (ORCID: https://orcid.org/0000-0002-3383-1287)
Institutions
- Chiba University (JP)
- University of San Diego (US)
- Louisiana State University in Shreveport (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- La Jolla Bioengineering Institute (US)
- Louisiana State University Health Sciences Center Shreveport (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3785
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56