Single-cell isolation reveals 5 fluorouracil-resistant subclones in oral squamous cell carcinoma: New insights into stemness and epithelial–mesenchymal transition for targeted therapies
Extended 5FU treatment in OSCC selects for distinct subclones that exhibit CSC-like traits and EMT-related motility, promoting robust chemoresistance and heightened malignancy. These findings emphasise the importance of developing comprehensive therapeutic strategies that simultaneously target drug-efflux mechanisms, CSC markers, and EMT pathways to more effectively control OSCC progression.
Authors
- Mingzhen Yang (ORCID: https://orcid.org/0009-0004-6636-3776)
- Hsin-Hu Chen
- Yi-Ming Chang (ORCID: https://orcid.org/0000-0002-4489-3985)
- Su-Feng Chen
- Wei‐Chia Su (ORCID: https://orcid.org/0000-0002-6375-1851)
- Jian-Hong Yu
- Yu‐Chun Lin (ORCID: https://orcid.org/0000-0002-1679-7064)
Institutions
- Tri-Service General Hospital (TW)
- China Medical University (TW)
- China Medical University Hospital (TW)
- Kaohsiung Municipal Ta-Tung Hospital (TW)
- Kaohsiung Veterans General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.jds.2025.05.032
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tri-Service General Hospital