The Effect of the Levonorgestrel-Releasing Intrauterine Device on Hypoactive Sexual Desire Disorder in Women

This research focused on the evaluation of the relationship between the levonorgestrel-releasing intrauterine device and Hypoactive Sexual Desire Disorder in women. Sexual desire disorder is part of a group of sexual dysfunctions. A group of 60 women with a diagnosis of hypoactive sexual desire were tested in the period from July 2023 to July 2024 at the Institute of Sexology of the 1st Faculty of Medicine in Prague. These patients were examined for levels of prolactin, sex hormone binding globulin, total testosterone, and markers CA-125 and CA-19-9. All patients completed the Rosen Female Sexual Function Index questionnaire on sexual dysfunction, as well as two questionnaires; one for traumatic stress and the other for somatoform dissociation. The results show significant Spearman correlations of trauma and psychosocial stress symptoms with dissociative symptoms (R = 0.52), with sex hormone-binding globulin (R = 0.80), and with sexual desire disorder score results (R = 0.65). The Spearman correlation of sex hormone-binding globulin with dissociative symptoms (R = 0.53) was also significant, as was the correlation between CA-125 and CA-19-9 (R = 0.45). The causal relationship regarding hypoactive sexual desire is not wholly resolved. We can assume that not only altered hormone levels, but also previous stressful experiences from sexual relationships and failure to fulfill sexual ideas and desires can play an important role. It is therefore necessary to pay close attention to the relationship between the levonorgestrel-releasing intrauterine device, sexual disorders, and social trauma and stress.