Ganoderic acid A regulates CSF1R to reprogram tumor-associated macrophages for immune therapy of hepatocellular carcinoma
Our findings suggest that GAA exerts immunotherapeutic effects in HCC by regulating macrophage polarization through CSF1R inhibition. As a promising natural bioactive compound with the potential to modulate the TME of HCC, GAA may provide novel insights into HCC immunotherapy through the reprogramming of TAMs.
Authors
- Lili Huang (ORCID: https://orcid.org/0000-0002-0007-4427)
- Shasha Tian
- Yifan Fei
- Yanzi Yang
- Hai An
- Zhihui Zhu (ORCID: https://orcid.org/0000-0002-3712-7238)
- Jiahui Lü (ORCID: https://orcid.org/0000-0002-0318-2335)
- Yaqin Yang
- Hongtao Hu (ORCID: https://orcid.org/0000-0003-3704-6646)
- Huajun Zhao
- Tinghuang Zhang
- Chenying Jiang
- H. Qin
Institutions
- Zhejiang Chinese Medical University (CN)
- Third People's Hospital of Hangzhou (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.intimp.2025.114989
- Citations
- 4
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Zhejiang Traditional Chinese Medicine Administration
- Natural Science Foundation of Zhejiang Province