Development of lisinopril radioconjugates for nuclear imaging of the angiotensin converting enzyme
[<sup>67</sup>Ga]Ga-DOTA-LIS-02 emerged as the most promising candidate to visualize ACE in mice. Further (pre)clinical studies will be necessary to validate the radioconjugate's potential for assessing ACE expression dynamics under pathophysiological conditions.
Authors
- Nicholas Philip van der Meulen (ORCID: https://orcid.org/0000-0001-6077-5594)
- Christian Vaccarin (ORCID: https://orcid.org/0000-0001-9876-7258)
- Niels J. Rupp (ORCID: https://orcid.org/0000-0002-7043-3456)
- Giovanni Marzaro (ORCID: https://orcid.org/0000-0002-5892-5992)
- Roger Schibli (ORCID: https://orcid.org/0000-0002-1537-3833)
- Chiara Favaretto (ORCID: https://orcid.org/0000-0002-5238-4136)
- Darja Beyer
- Cristina Mueller (ORCID: https://orcid.org/0000-0001-9357-9688)
- A. Yu. Moiseeva (ORCID: https://orcid.org/0000-0003-0718-5258)
- Benjamin D. Hunkeler
Institutions
- University of Verona (IT)
- University of Zurich (CH)
- Paul Scherrer Institute (CH)
- University Hospital of Basel (CH)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-06-07
- DOI
- https://doi.org/10.1007/s00259-025-07386-w
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Eidgenössische Technische Hochschule Zürich