Prenatal poly(I:C) exposure, rather than altered maternal care, causes offspring behavioural and cognitive deficits in a rat model of neurodevelopmental disorders
The prenatal maternal response to MIA drives developmental and cognitive deficits. Offspring USVs influenced maternal care behaviours, but postnatal rearing did not affect cognitive development. USV trait clustering predicted adult social deficits, highlighting its potential for identifying at-risk and resilient offspring in NDDs.
Authors
- Grace Revill (ORCID: https://orcid.org/0000-0001-5970-2320)
- Reinmar Hager (ORCID: https://orcid.org/0000-0002-6692-5669)
- Harry G. Potter (ORCID: https://orcid.org/0000-0002-8398-0264)
- Joanna Caroline Neill (ORCID: https://orcid.org/0000-0002-2717-9739)
- Rebecca M. Woods (ORCID: https://orcid.org/0000-0002-8413-4852)
- Jocelyn D. Glazier (ORCID: https://orcid.org/0000-0002-4215-5727)
- Jarred M. Lorusso (ORCID: https://orcid.org/0000-0002-6770-4139)
- Michael Harte (ORCID: https://orcid.org/0000-0002-4702-4785)
Institutions
- Manchester Academic Health Science Centre (GB)
- University College London (GB)
- University of Brighton (GB)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.bbi.2025.06.005
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- UK Research and Innovation
- University of Manchester
- Biotechnology and Biological Sciences Research Council