Comprehensive molecular characterization of post-COVID condition: Immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
This study defines a molecular profile of PCC, marked by immunoglobulin downregulation and the persistence of SARS-CoV-2 antigens, which may contribute to ongoing immune alterations in PCC. The severity metric derived from proteomic profiling provides a tool for categorizing PCC patients based on symptom severity and could support future studies aimed at targeted interventions.
Authors
- Paula Antelo-Riveiro
- Rebeca García‐Fandiño (ORCID: https://orcid.org/0000-0002-5274-3928)
- Alejandro Seco-González (ORCID: https://orcid.org/0009-0002-8344-7010)
- María Jesús Domínguez-Santalla
- Susana B. Bravo (ORCID: https://orcid.org/0000-0001-7615-3079)
- Ángel Piñeiro (ORCID: https://orcid.org/0000-0001-9350-8468)
- Emilio Rodríguez‐Ruiz (ORCID: https://orcid.org/0000-0003-1447-877X)
Institutions
- Universidade de Santiago de Compostela (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Center for Research in Molecular Medicine and Chronic Diseases (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Servicio Gallego de Salud (ES)
- Centro Singular de Investigación en Química Biológica y Materiales Moleculares
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.jiph.2025.102870
- Citations
- 2
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- European Commission
- Consellería de Economía, Emprego e Industria, Xunta de Galicia
- Xunta de Galicia
- European Regional Development Fund
- Agencia Estatal de Investigación