Prostate Assessment using Comparative Interventions – Fast MRI and Image-fusion for Cancer (IP7-PACIFIC): A prospective, multi-centre, dual sequential randomised controlled trial
IP7-PACIFIC aims to provide randomised comparative evidence for the clinical utility and cost-effectiveness of using bpMRI and image-fusion biopsy. The findings will inform guidelines. The sequential randomised co-enrolment design allows simultaneous evaluation of two research questions and avoids heterogeneity of trial populations. By contrast to previous paired-cohort studies, the randomised design will reduce reporter bias, providing the highest level of diagnostic evidence.
Authors
- Luke Vale (ORCID: https://orcid.org/0000-0001-8574-8429)
- Darren Walls (ORCID: https://orcid.org/0009-0009-3555-3135)
- Francesca Rawlins
- Hashim U. Ahmed (ORCID: https://orcid.org/0000-0003-1674-6723)
- Emma Cullen
- Emily Mitchell (ORCID: https://orcid.org/0000-0003-0379-3790)
- Derek Price
- Andrea Rockall (ORCID: https://orcid.org/0000-0001-8270-5597)
- Taimur T. Shah (ORCID: https://orcid.org/0000-0003-1642-1208)
- Natalia Klimowska‐Nassar (ORCID: https://orcid.org/0000-0003-3655-7436)
- Mathias Winkler (ORCID: https://orcid.org/0000-0002-2553-5816)
- Rhian Gabe (ORCID: https://orcid.org/0000-0002-0273-3094)
- Anwar R. Padhani (ORCID: https://orcid.org/0000-0002-5830-5777)
- Andrew Smith (ORCID: https://orcid.org/0000-0003-0352-4849)
- Robert Oldroyd (ORCID: https://orcid.org/0000-0002-4969-3544)
- Alexander Light (ORCID: https://orcid.org/0000-0001-7246-3651)
- Nikhil Mayor (ORCID: https://orcid.org/0000-0003-2681-2501)
- Thiagarajah Sasikaran
- Puja Jadav
- Heminder Sokhi (ORCID: https://orcid.org/0000-0003-0424-8356)
- Rakesh Heer (ORCID: https://orcid.org/0000-0003-1952-7462)
- Paul H. Robinson (ORCID: https://orcid.org/0000-0002-2673-2205)
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Queen Mary University of London (GB)
- Hillingdon Hospitals NHS Foundation Trust (GB)
- Mount Vernon Hospital (GB)
- London School of Hygiene & Tropical Medicine (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Contemporary Clinical Trials
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.cct.2025.107983
- Citations
- 2
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Cancer Research UK