Endothelial c-Maf prevents MASLD-like liver fibrosis by regulating chromatin accessibility to suppress pathogenic microvascular cell subsets
This work builds on the known importance of liver sinusoidal endothelial cells in liver function and disease. Here, transcription factor c-Maf is identified as a master regulator in maintaining normal differentiation and zonation of liver sinusoidal endothelial cells, thereby protecting against the development of liver fibrosis/cirrhosis. The findings are significant for researchers and clinicians focusing on liver disease, as they suggest potential new targets for therapeutic intervention. These findings could instruct the development of novel preventive treatment options and antifibrotic therapy regimens as well as liver repair strategies, benefiting patients, clinicians and policy makers in the management of liver disease.
Authors
- Anna M. Randi
- Manuel Winkler (ORCID: https://orcid.org/0000-0003-2415-9350)
- Philipp‐Sebastian Koch (ORCID: https://orcid.org/0000-0001-5236-0516)
- Rita Manco (ORCID: https://orcid.org/0000-0003-0857-6322)
- Inês Cebola (ORCID: https://orcid.org/0000-0003-3528-4982)
- Michelle Neßling (ORCID: https://orcid.org/0000-0002-0663-4026)
- Hannah Maude (ORCID: https://orcid.org/0000-0002-7593-4516)
- Sina W. Kürschner (ORCID: https://orcid.org/0000-0002-4546-9684)
- Gergana D. Dobreva (ORCID: https://orcid.org/0000-0002-4814-9416)
- Julio Cordero (ORCID: https://orcid.org/0000-0002-2136-1783)
- Christian David Schmid (ORCID: https://orcid.org/0000-0002-4401-3394)
- Theresa Staniczek (ORCID: https://orcid.org/0000-0002-3137-3833)
- Carsten Sticht (ORCID: https://orcid.org/0000-0003-3596-6094)
- Sergij Goerdt (ORCID: https://orcid.org/0000-0002-5718-415X)
- Dorka Nagy (ORCID: https://orcid.org/0000-0002-5373-9664)
- Kai Schledzewski (ORCID: https://orcid.org/0000-0002-0107-1674)
- Johannes Hoffmann (ORCID: https://orcid.org/0000-0002-2774-7847)
- Karsten Richter (ORCID: https://orcid.org/0000-0002-1049-8151)
- Maximilian Suhayda
- Linda Kraske
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Evangelisches Krankenhaus Düsseldorf (DE)
- Genomics (United Kingdom) (GB)
- University Medical Centre Mannheim (DE)
- Directorate-General Joint Research Centre (BE)
- Imperial College London (GB)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101475
- Citations
- 1
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Wellcome Trust
- British Heart Foundation
- Imperial College London
- Deutsche Forschungsgemeinschaft
- Fonds De La Recherche Scientifique - FNRS