MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker
Our findings suggest that miR-15a is a potential biomarker of AAA. Through in vivo studies and based on its target profile, we show that miR-15a is involved in AAA pathogenesis and could help treatment, but also assist in risk-stratification of AAA patients and identify candidates for early AAA repair.
Authors
- Joost P. G. Sluijter (ORCID: https://orcid.org/0000-0003-2088-9102)
- Nadja Sachs (ORCID: https://orcid.org/0000-0001-8031-017X)
- Reinier A. Boon (ORCID: https://orcid.org/0000-0001-7944-9748)
- Christine Brostjan (ORCID: https://orcid.org/0000-0003-1462-5397)
- Ekaterina Chernogubova (ORCID: https://orcid.org/0000-0002-3051-653X)
- Hong Jin (ORCID: https://orcid.org/0000-0002-8878-6436)
- Tooba Khan (ORCID: https://orcid.org/0009-0005-8460-3662)
- Lars Mäegdefessel (ORCID: https://orcid.org/0000-0001-5228-2634)
- Suzanne M. Eken (ORCID: https://orcid.org/0000-0002-5851-7630)
- Valentina Paloschi (ORCID: https://orcid.org/0000-0002-5778-8981)
- Moritz Lindquist Liljeqvist (ORCID: https://orcid.org/0000-0001-6821-6674)
- Rebecka Hultgren (ORCID: https://orcid.org/0000-0002-8869-0493)
- Philip S. Tsao (ORCID: https://orcid.org/0000-0001-7274-9318)
- Greg Winski (ORCID: https://orcid.org/0000-0002-1832-5423)
- Alexandra Bäcklund
- Joshua M. Spin (ORCID: https://orcid.org/0000-0002-4256-9161)
- Joy Roy
- Hans‐Henning Eckstein
- Albert Busch (ORCID: https://orcid.org/0000-0003-0818-891X)
- Gert J de Borst
- Folkert W Asselbergs
Institutions
- Goethe University Frankfurt (DE)
- Karolinska University Hospital (SE)
- Utrecht University (NL)
- VA Palo Alto Health Care System (US)
- Cardiovascular Institute of the South (US)
- TUM Klinikum (DE)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- National Institute for Health and Care Research (GB)
- German Centre for Cardiovascular Research (DE)
- University Hospital Carl Gustav Carus (DE)
- University College London (GB)
- Technical University of Munich (DE)
- Medical University of Vienna (AT)
- Technische Universität Dresden (DE)
- University of Amsterdam (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Stanford University (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1038/s43856-025-00892-w
- Citations
- 7
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Karolinska Institutet
- Vetenskapsrådet
- Council for Science and Technology Policy
- National Institutes of Health