The Essential Role of Immunomodulatory Tregs in Visual Deficits After Military-Relevant Trauma
Our studies suggest that depletion of Treg cells followed by blast injury leads to increased retinal degeneration and neuroinflammation. This highlights the continuous requirement of Foxp3 + Treg cell activity to prevent neurodegeneration in mTBI. Future studies should fully explore the relationship of immunomodulatory Treg cells with neurodegeneration in blast-associated visual deficits. Therapeutics aiming to modulate Treg cells could be tested in DEREG transgenic mice after blast injury.
Authors
- Nawajes A. Mandal (ORCID: https://orcid.org/0000-0003-4489-7748)
- Nobel A. Del Mar
- Amanda Prislovsky
- Rajashekhar Gangaraju (ORCID: https://orcid.org/0000-0002-6664-8286)
- Amritha T. M. Seetharaman
- Mohammad Shahadat Hossain (ORCID: https://orcid.org/0000-0002-8762-8989)
- Yasaman Anvarinia
Institutions
- Massachusetts Eye and Ear Infirmary (US)
- University of Tennessee Health Science Center (US)
- Memphis VA Medical Center (US)
Publication Details
- Journal
- Military Medicine
- Published
- 2025-05-21
- DOI
- https://doi.org/10.1093/milmed/usaf254
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- National Eye Institute
- National Institute of Neurological Disorders and Stroke
- Congressionally Directed Medical Research Programs