Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual's lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (<i>n</i> = 752) and longitudinal (<i>n</i> = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.

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Publication Details

Journal
Science Advances
Published
2025-06-06
DOI
https://doi.org/10.1126/sciadv.adr8164
Citations
9
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
12.88
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article

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Andreas Heinz, Sylvane Desrivières, Amin Saberi, Hugh P Garavan et al.
9 citations
Science Advances
Functional Brain Connectivity Studies
12.88
article

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Andreas Heinz, Sylvane Desrivières, Amin Saberi, Hugh P Garavan, Boris C. Bernhardt, Simon Bodo Eickhoff, Rüdiger Brühl, Tomáš Paus, Leon D. Lotter, Oleksandr V. Popovych, H. Lina Schaare, Tobias Banaschewski, Christian Bäuchl, Sarah Hohmann, Sofie Louise Valk, Jean‐Luc Martinot, Marie‐Laure Paillère Martinot, Arun L.W. Bokde, Nathalie Holz, Herta Flor, Antoine Grigis, Robert Whelan, Henrik Walter, Luise Poustka, Juergen Dukart, Hervé Lemaître, Michael N. Smolka, Kevin J. Wischnewski, Dimitri Papadopoulos Orfanos, Frauke Nees, Gareth J. Barker, Penny Anne Gowland, Eric Artiges A, Kyesam Jung, Günter Schumann, Nilakshi Vaidya
article en
9 citations

Abstract

The excitation-inhibition ratio is a key functional property of cortical microcircuits which changes throughout an individual's lifespan. Adolescence is considered a critical period for maturation of excitation-inhibition ratio. This has primarily been observed in animal studies. However, there is limited human in vivo evidence for maturation of excitation-inhibition ratio at the individual level. Here, we developed an individualized in vivo marker of regional excitation-inhibition ratio in human adolescents, estimated using large-scale simulations of biophysical network models fitted to resting-state functional imaging data from both cross-sectional (<i>n</i> = 752) and longitudinal (<i>n</i> = 149) cohorts. In both datasets, we found a widespread decrease in excitation-inhibition ratio in association areas, paralleled by an increase or lack of change in sensorimotor areas. This developmental pattern was aligned with multiscale markers of sensorimotor-association differentiation. Although our main findings were robust across alternative modeling configurations, we observed local variations, highlighting the importance of methodological choices for future studies.

Science AdvancesVol. 11(23)
University of Vermont (US), Physikalisch-Technische Bundesanstalt (DE), Montreal Neurological Institute and Hospital (CA), Centre National de la Recherche Scientifique (FR), University of Nottingham (GB), Université de Bordeaux (FR), Inserm (FR), University of Mannheim (DE), King's College London (GB), Trinity College Dublin (IE), Heidelberg University (DE), University of Cambridge (GB), Fudan University (CN), Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR), Université Paris-Saclay (FR), University Hospital Heidelberg (DE), Centre Hospitalier Universitaire Sainte-Justine (CA), Christian-Albrechts-Universität zu Kiel (DE), Centre for Mental Health (GB), Humboldt-Universität zu Berlin (DE), Sorbonne Université (FR), Institut des Maladies Neurodégénératives (FR), Düsseldorf University Hospital (DE), Assistance Publique – Hôpitaux de Paris (FR), Central Institute of Mental Health (DE), Pitié-Salpêtrière Hospital (FR), German Centre for Cardiovascular Research (DE), CEA Paris-Saclay (FR), Max Planck Institute for Human Cognitive and Brain Sciences (DE), Jülich Aachen Research Alliance (DE), Laboratoire de Biologie et Pharmacologie Appliquée (FR), Shanghai Center for Brain Science and Brain-Inspired Technology (CN), Heinrich Heine University Düsseldorf (DE), McGill University (CA), Université de Montréal (CA), Technische Universität Dresden (DE), Charité - Universitätsmedizin Berlin (DE)
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