Impact of image reconstruction on cerebral blood flow measured with 15O-water positron emission tomography
This study concludes that grey matter and central white matter CBF, but not whole brain CBF measured with quantitative <sup>15</sup>O-water PET is reconstruction method dependent, mainly due to varying spatial resolution with consequent partial volume effects. Variations in published CBF values cannot be explained solely by reconstruction methods or spatial resolution.
Authors
- Elin Lindström (ORCID: https://orcid.org/0000-0002-0384-8045)
- Andreas Tolf (ORCID: https://orcid.org/0000-0002-0580-8821)
- My Jonasson (ORCID: https://orcid.org/0000-0003-3259-2613)
- Lieuwe Appel (ORCID: https://orcid.org/0009-0008-9933-4137)
- Joachim Burman (ORCID: https://orcid.org/0000-0002-7045-1806)
- Mark Lubberink (ORCID: https://orcid.org/0000-0001-8324-7399)
- Eduardo Donato Eing Engelke Back
Institutions
- Uppsala University (SE)
- Department of Medical Sciences (RU)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s40658-025-00760-5
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Svenska Sällskapet för Medicinsk Forskning
- Akademiska Sjukhuset
- Uppsala Universitet
- Marcus och Amalia Wallenbergs minnesfond