The EGR1-mediated lncRNA TENM3-AS1 potentiates gastric cancer metastasis via reprogramming fatty acid metabolism
In this study, by comparing lncRNA sequencing data from paired primary and peritoneal metastatic tumors and public transcriptome data from non-metastatic and metastatic samples, we clarified a novel lncRNA, TENM3-AS1. It was found that TENM3-AS1 was aberrantly activated in metastatic and advanced primary tumors, and was strongly correlated with a shorter survival in GC patients. Our study reveals the EGR1/TENM3-AS1/ hnRNPK/FASN axis as a novel curative target in metastatic GC.
Authors
- Yongming Chen (ORCID: https://orcid.org/0000-0002-2143-3134)
- Yi Xie (ORCID: https://orcid.org/0000-0003-1936-0121)
- Yuhui Tang (ORCID: https://orcid.org/0009-0001-2181-4068)
- Wanchuan Wang
- Junsheng Zhang (ORCID: https://orcid.org/0000-0001-8740-2851)
- Xiaohui Zhai (ORCID: https://orcid.org/0000-0003-0078-0441)
- Hao Chen (ORCID: https://orcid.org/0009-0001-6480-7976)
- Baiwei Zhao (ORCID: https://orcid.org/0009-0004-2125-8657)
- Yuanfang Li (ORCID: https://orcid.org/0000-0003-1762-2634)
- Wen Zhou (ORCID: https://orcid.org/0000-0001-8128-5797)
- Feizhi Lin
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1186/s12943-025-02341-7
- Citations
- 7
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province