Characterization of TNSALP expression and activity in porcine utero-placental tissues
Phosphate is an essential nutrient for fetal growth, but how it is managed during pregnancy is not fully understood. This study explored the role of an enzyme called tissue non-specific alkaline phosphatase (TNSALP) in regulating phosphate availability in the uterus and placenta in pigs in mid- and late pregnancy. Phosphate levels decreased in the fluids surrounding the fetus in late pregnancy. TNSALP was present in the uterus and placenta, and the amount of the enzyme varied depending on the tissue and stage of pregnancy and correlated with changes in phosphate levels. These findings suggest that TNSALP plays a key role in managing phosphate transport from the mother to the fetus in pregnancy to support fetal development.
Authors
- Nirvay Sah (ORCID: https://orcid.org/0000-0002-2788-3646)
- Fuller W. Bazer (ORCID: https://orcid.org/0000-0002-5823-5086)
- Katherine M Halloran (ORCID: https://orcid.org/0000-0002-4050-1892)
- Gregory A. Johnson (ORCID: https://orcid.org/0000-0003-1949-1797)
- Robyn M Moses
- Makenzie G Newton
- Heewon Seo (ORCID: https://orcid.org/0000-0002-2639-0065)
- Joe W Cain
- Claire Stenhouse (ORCID: https://orcid.org/0000-0001-8302-7900)
- Guoyao Wu
Institutions
- Pennsylvania State University (US)
- University of Kentucky (US)
- Texas A&M University System (US)
- Texas College (US)
- University of California San Diego (US)
- University of Nebraska Medical Center (US)
- University of Maryland, College Park (US)
- Texas A&M University (US)
Publication Details
- Journal
- Reproduction and Fertility
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1530/raf-25-0005
- Primary Topic
- Alkaline Phosphatase Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00